Pharmachologic effect:
Antitumor agent. Belongs to the group of platinum derivatives. The mechanism of action is associated with the formation of “crosslinks” between adjacent base pairs of guanine in DNA (deoxyribonucleic acid, an integral part of the cell nucleus responsible for the transfer of hereditary information), which leads to suppression of nucleic acid biosynthesis and cell death. Unlike the drug cisplatin, it has less nephrotoxicity (damaging effect on the kidneys), ototoxicity (damaging effect on the hearing organs) and neurotoxicity (damaging effect on the nervous system).
Indications for use:
Ovarian cancer, germ cell tumor (a malignant tumor formed from germ cells) of the testis and ovaries, seminoma (a malignant tumor that develops from testicular tissue that produces male sex cells – sperm), melanoma (cancer that develops from pigment-forming cells), tumors of the head and neck, lung cancer, cervical cancer, bladder cancer, osteogenic sarcoma (a malignant tumor arising from osteoblasts – bone cells).
Mode of application:
The drug is taken only intravenously. Adults – 400 mg / m2 of body surface for 15-60 minutes. The next dose of the drug is administered no earlier than 4 weeks later. In the case of previous treatment with drugs that have a myelosuppressive (suppressive activity of the bone marrow) effect, the dose of carboplatin is reduced by 20-25%.
The contents of the vial should be dissolved immediately before use in sterile water for injection, 5% glucose solution, isotonic sodium chloride solution to a final concentration (10 mg / ml). The prepared solution must be used within 8 hours. It is not recommended to prescribe simultaneously with other drugs that have myelosuppressive (suppressive activity of the bone marrow), nephrotoxic (damaging effect on the kidneys), neurotoxic (damaging effect on the central nervous system) action.
The drug is used only under the supervision of a physician experienced in chemotherapy. Before starting treatment and during it, it is necessary to evaluate the functional characteristics of the kidneys, determine the content of blood cells, and carry out a neurological examination. Needles or IV sets must not contain aluminum.
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